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testDeltaNotch1.cpp
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Sat, Nov 16, 16:17
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Mon, Nov 18, 16:17 (2 d)
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blob
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R9411 tisue modeling
testDeltaNotch1.cpp
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#include "deltaNotch1.hpp"
using
namespace
std
;
using
namespace
boost
::
numeric
::
odeint
;
//integrate<void (&)(const state_type&),state_type,double,double,double> mintegrate;
void
dummy
(
const
state_type
&
x
,
state_type
&
dxdt
,
const
double
t
){
for
(
int
i
=
0
;
i
<
5
;
i
++
){
dxdt
[
i
]
=
-
0.01
*
x
[
i
];
}
}
void
DeltaNotch1
::
operator
()
(
const
state_type
&
y
,
state_type
&
dydt
,
const
double
t
)
{
double
ddi
,
dni
,
dnidi
,
dnidj
,
dsi
;
double
di
=
y
[
0
];
double
ni
=
y
[
1
];
double
nidi
=
y
[
2
];
double
nidj
=
y
[
3
];
double
si
=
y
[
4
];
//// delta
ddi
=
bd
-
gd
*
di
;
// production and degr.
ddi
=
ddi
+
ktm
*
njdi
-
ktp
*
di
*
nj
;
// trans binding
ddi
=
ddi
+
ks
*
njdi
;
//release after cleaving
ddi
=
ddi
-
kcp
*
ni
*
di
+
kcm
*
nidi
;
//// cis binding
//// notch
dni
=
bn
-
gn
*
ni
;
dni
=
dni
+
ktm
*
nidj
-
ktp
*
dj
*
ni
;
// trans binding
dni
=
dni
-
kcp
*
ni
*
di
+
kcm
*
nidi
;
// cis binding
dni
=
dni
+
diffu
*
(
np
+
nn
-
2
*
ni
);
//diffusion
//// cis complex
dnidi
=
kcp
*
ni
*
di
-
kcm
*
nidi
-
ki
*
nidi
;
//// trans complex
dnidj
=
-
ktm
*
nidj
+
ktp
*
dj
*
ni
-
ks
*
nidj
;
//// cleaved notch
dsi
=
ks
*
nidj
-
gs
*
si
;
////
dydt
[
0
]
=
ddi
;
dydt
[
1
]
=
dni
;
dydt
[
2
]
=
dnidi
;
dydt
[
3
]
=
dnidj
;
dydt
[
4
]
=
dsi
;
}
void
writeState
(
const
state_type
y
,
const
double
t
){
cout
<<
t
<<
" "
;
for
(
uint
i
=
0
;
i
<
y
.
size
();
i
++
){
cout
<<
y
[
i
]
<<
" "
;
}
cout
<<
endl
;
}
int
main
(
int
argc
,
char
*
arg
[]){
DeltaNotch1
dn
;
state_type
y
=
{{
1.0
,
1.0
,
0.0
,
0.0
,
0.0
}};
dn
.
setContext
(
1.02
,
0.98
,
0
,
0.3
,
0
,
0
);
// size_t nsteps=integrate(dummy,y,0.0 , 10.0 , 0.1);
integrate
(
dn
,
y
,
0.0
,
10.0
,
0.1
,
writeState
);
// for(uint i=0;i<5;i++){
// cout<<y[i]<<" ";
// }
// cout<<endl;
}
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