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= Lossy Image Compression = There is a [[https://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-7-29 | great article]] by Johan Lundin, Research Director at FIMM which explains the effects of lossy compression on digital pathology images and sets a good practice threshold.

= Lossy Image Compression = There is a [[https://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-7-29 | great article]] by Johan Lundin, Research Director at FIMM which explains the effects of lossy compression on digital pathology images and sets a good practice threshold. === Conclusions Summarized === - Images stored for the automated IHC analysis can be compressed and scaled significantly without compromising reliable computer-assisted analysis results - Object area measurement does not seem to be affected by image compression, [[ http://link.springer.com/article/10.1007%2Fs00418-009-0626-9 |whereas object roundness does]] - Lossy compression should be performed only once per image in the image processing workflow. If subsequent saving of images is needed, a lossless compression should be used. - Assessment of segmented IHC stained nuclei in regions of densely packed cells in compressed images [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585525/ |is causing significant discrepancy]]. - The IHC algorithm used in this study calculates the percentage of the gross area of stained tissue. Thus, modest image degradation does not seem to affect the algorithm.

= Lossy Image Compression = There is a [[https://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-7-29 | great article]] by Johan Lundin, Research Director at FIMM which explains the effects of lossy compression on digital pathology images and sets a good practice threshold. === Conclusions Summarized === - Images stored for the automated IHC analysis can be compressed and scaled significantly without compromising reliable computer-assisted analysis results - Object area measurement does not seem to be affected by image compression, [[ http://link.springer.com/article/10.1007%2Fs00418-009-0626-9 |whereas object roundness does]] - Lossy compression should be performed only once per image in the image processing workflow. If subsequent saving of images is needed, a lossless compression should be used. - Assessment of segmented IHC stained nuclei in regions of densely packed cells in compressed images [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585525/ |is causing significant discrepancy]]. - The IHC algorithm used in this study calculates the percentage of the gross area of stained tissue. Thus, modest image degradation does not seem to affect the algorithm.