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nmodl_generator.py
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Sat, Nov 16, 19:57

nmodl_generator.py
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# -*- coding: utf-8 -*-
# @Author: Theo Lemaire
# @Date: 2019-03-18 21:17:03
# @Last Modified by: Theo Lemaire
# @Last Modified time: 2019-06-12 12:14:36
import inspect
import re
from time import gmtime, strftime
def escaped_pow(x):
return ' * '.join([x.group(1)] * int(x.group(2)))
class NmodlGenerator:
tabreturn = '\n '
NEURON_protected_vars = ['O', 'C']
def __init__(self, pneuron):
self.pneuron = pneuron
self.translated_states = [self.translateState(s) for s in self.pneuron.states]
def print(self, outfile):
all_blocks = [
self.title(),
self.description(),
self.constants(),
self.tscale(),
self.neuron_block(),
self.parameter_block(),
self.state_block(),
self.assigned_block(),
self.function_tables(),
self.initial_block(),
self.breakpoint_block(),
self.derivative_block()
]
with open(outfile, "w") as fh:
fh.write('\n\n'.join(all_blocks))
def translateState(self, state):
return '{}{}'.format(state, '1' if state in self.NEURON_protected_vars else '')
def title(self):
return 'TITLE {} membrane mechanism'.format(self.pneuron.name)
def description(self):
return '\n'.join([
'COMMENT',
self.pneuron.getDesc(),
'',
'@Author: Theo Lemaire, EPFL',
'@Date: {}'.format(strftime("%Y-%m-%d", gmtime())),
'@Email: theo.lemaire@epfl.ch',
'ENDCOMMENT'
])
def constants(self):
block = [
'FARADAY = 96494 (coul) : moles do not appear in units',
'R = 8.31342 (J/mol/K) : Universal gas constant'
]
return 'CONSTANT {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))
def tscale(self):
return 'INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}'
def neuron_block(self):
block = [
'SUFFIX {}'.format(self.pneuron.name),
'',
': Constituting currents',
*['NONSPECIFIC_CURRENT {}'.format(i) for i in self.pneuron.getCurrentsNames()],
'',
': RANGE variables',
'RANGE Adrive, Vmeff : section specific',
'RANGE stimon : common to all sections (but set as RANGE to be accessible from caller)'
]
return 'NEURON {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))
def parameter_block(self):
block = [
': Parameters set by python/hoc caller',
'stimon : Stimulation state',
'Adrive (kPa) : Stimulation amplitude',
'',
': Membrane properties',
'cm = {} (uF/cm2)'.format(self.pneuron.Cm0 * 1e2)
]
# Reversal potentials
possibles_E = list(set(['Na', 'K', 'Ca'] + [i[1:] for i in self.pneuron.getCurrentsNames()]))
for x in possibles_E:
nernst_pot = 'E{}'.format(x)
if hasattr(self.pneuron, nernst_pot):
block.append('{} = {} (mV)'.format(
nernst_pot, getattr(self.pneuron, nernst_pot)))
# Conductances / permeabilities
for i in self.pneuron.getCurrentsNames():
suffix = '{}{}'.format(i[1:], '' if 'Leak' in i else 'bar')
factors = {'g': 1e-4, 'p': 1e2}
units = {'g': 'S/cm2', 'p': 'cm/s'}
for prefix in ['g', 'p']:
attr = '{}{}'.format(prefix, suffix)
if hasattr(self.pneuron, attr):
val = getattr(self.pneuron, attr) * factors[prefix]
block.append('{} = {} ({})'.format(attr, val, units[prefix]))
return 'PARAMETER {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))
def state_block(self):
block = [': Standard gating states', *self.translated_states]
return 'STATE {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))
def assigned_block(self):
block = [
': Variables computed during the simulation and whose value can be retrieved',
'Vmeff (mV)',
'v (mV)',
*['{} (mA/cm2)'.format(i) for i in self.pneuron.getCurrentsNames()]
]
return 'ASSIGNED {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))
def function_tables(self):
block = [
': Function tables to interpolate effective variables',
'FUNCTION_TABLE V(A(kPa), Q(nC/cm2)) (mV)',
*['FUNCTION_TABLE {}(A(kPa), Q(nC/cm2)) (mV)'.format(r) for r in self.pneuron.rates]
]
return '\n'.join(block)
def initial_block(self):
block = [': Set initial states values']
for s in self.pneuron.states:
if s in self.pneuron.getGates():
block.append('{0} = alpha{1}(0, v) / (alpha{1}(0, v) + beta{1}(0, v))'.format(
self.translateState(s), s.lower()))
else:
block.append('{} = ???'.format(self.translateState(s)))
return 'INITIAL {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))
def breakpoint_block(self):
block = [
': Integrate states',
'SOLVE states METHOD cnexp',
'',
': Compute effective membrane potential',
'Vmeff = V(Adrive * stimon, v)',
'',
': Compute ionic currents'
]
for i in self.pneuron.getCurrentsNames():
func_exp = inspect.getsource(getattr(self.pneuron, i)).splitlines()[-1]
func_exp = func_exp[func_exp.find('return') + 7:]
func_exp = func_exp.replace('self.', '').replace('Vm', 'Vmeff')
func_exp = re.sub(r'([A-Za-z][A-Za-z0-9]*)\*\*([0-9])', escaped_pow, func_exp)
block.append('{} = {}'.format(i, func_exp))
return 'BREAKPOINT {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))
def derivative_block(self):
block = [': Gating states derivatives']
for s in self.pneuron.states:
if s in self.pneuron.getGates():
block.append(
'{0}\' = alpha{1}{2} * (1 - {0}) - beta{1}{2} * {0}'.format(
self.translateState(s), s.lower(), '(Adrive * stimon, v)')
)
else:
block.append('{}\' = ???'.format(self.translateState(s)))
return 'DERIVATIVE states {{{}{}\n}}'.format(self.tabreturn, self.tabreturn.join(block))

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